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Hypersensitivity Reaction Type Pathophysiology Clinical Examples Type I (anaphylactic and atopic)
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Sorry, this question is for Upgrade to PEAK Sorry, this question is for Upgrade to PEAK Sorry, this question is for Upgrade to PEAK Sorry, this question is for Upgrade to PEAK Sorry, this question is for Upgrade to PEAK (M1.IM.17.4767) A mother brings her 6-year-old son to the pediatrician with a 7 week history of cough and shortness of breath. The mother says that his cough is dry and worse at night when it sometimes wakes him up from sleep. The cough has not been associated with a fever and growth charts reveal that he is growing well. Past history is significant only for travel to many countries on vacation over the last few years. Physical exam reveals end expiratory wheezing and the finding shown in Figure A. The most likely cause of this patient’s symptoms is an example of which of the following types of disorders? QID: 109089 FIGURES: Type & Select Correct Answer Type in at least one full word to see suggestions list Return multiple choice1 Type I hypersensitivity 53% (126/236) 2 Type II cytotoxic hypersensitivity 9% (22/236) 3 Type II non-cytotoxic hypersensitivity 8% (18/236) 4 Type III hypersensitivity 11% (25/236) 5 Type IV hypersensitivity 17% (39/236) M 2 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 1 Review Tested Concept Review Full Topic (M1.IM.14.61) You are working in the emergency room of a children's hospital when a 4-year-old girl is brought in by ambulance due to "difficulty breathing." The patient had been eating lunch on a school field trip when she suddenly complained of abdominal pain. Shortly thereafter, she was noted to have swelling of the lips, a rapidly developing red rash and difficulty breathing. In the ambulance her blood pressure was persistently 80/50 mmHg despite intramuscular epinephrine. In the course of stabilization and work up of the patient, you note an elevated tryptase level. What is the mechanism behind this elevated tryptase level? QID: 100864 Type & Select Correct Answer Type in at least one full word to see suggestions list 1 IgG production by plasma cells 1% (1/159) 2 IgM mediated complement activation 4% (6/159) 3 Cross-linking of IgE on mast cells 87% (139/159) 4 Antibody-antigen immune complexes 4% (6/159) 5 Cross-linking of IgG on mast cells 3% (4/159) M 1 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review Tested Concept Review Full Topic (M1.IM.14.60) A 5-year-old African American female has experienced recurrent respiratory infections. To determine how well her cell-mediated immunity is performing, a Candida skin injection is administered. After 48 hours, there is no evidence of induration at the injection site. Of the following cell types, which one would have mediated the reaction? QID: 100481 Type & Select Correct Answer Type in at least one full word to see suggestions list 1 Plasma cells 6% (8/135) 2 Basophils 2% (3/135) 3 T-cells 75% (101/135) 4 Mast cells 13% (18/135) 5 Fibroblasts 1% (1/135) M 2 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review Tested Concept Review Full Topic (M1.IM.14.1) While playing in the woods with friends, a 14-year-old African-American male is bitten by an insect. Minutes later he notices swelling and redness at the site of the insect bite. Which substance has directly led to the wheal formation? QID: 100422 Type & Select Correct Answer Type in at least one full word to see suggestions list 1 IFN-gamma 4% (6/144) 2 Histamine 87% (125/144) 3 IL-22 0% (0/144) 4 Arachidonic acid 3% (4/144) 5 IL-4 6% (8/144) M 1 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic (M1.IM.14.1) A 32-year-old female presents with a three month history of oral ulcerations and blisters throughout her body. When the physician examined the skin, she noted that when the skin was rubbed it sloughed off and formed blisters within a few minutes. A skin biopsy was performed and analyzed via immunofluorescence using anti-IgG antibodies (Figure A). Which of the following antibodies is also involved or found in a similar type of hypersensitivity reaction as in the case mentioned? QID: 106310 FIGURES: Type & Select Correct Answer Type in at least one full word to see suggestions list Return multiple choice1 IgE against the proteins in apitoxin 4% (6/134) 2 Anti-glomerular basement membrane 65% (87/134) 3 Anti-dsDNA 12% (16/134) 4 IgE against pollen 7% (10/134) 5 Anti-Smith 7% (9/134) M 1 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic Sorry, this question is for Upgrade to PEAK (M1.IM.14.29) A 28-year-old female suffering from a urinary tract infection is given trimethoprim-sulfamethoxazole (TMP-SMX) by her physician. Several days later, she begins to experience itchiness and joint pain. Laboratory and histologic analysis reveals vasculitis and antibody complexes deposited near the basement membrane of the glomerulus. What other serological finding is expected with this presentation? QID: 100450 Type & Select Correct Answer Type in at least one full word to see suggestions list 1 Decreased levels of IgE 0% (1/200) 2 Increased levels of IgE 12% (24/200) 3 Decreased neutrophil count 4% (8/200) 4 Increased serum levels of complement protein C3 29% (58/200) 5 Lowered serum levels of complement protein C3 52% (105/200) M 2 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 5 Review Tested Concept Review Full Topic (M1.IM.13.50) While hunting, a 45-year-old Caucasian man is stung by a bee. He begins to feel unwell and is taken to the hospital. Upon arrival, it is noted that the patient is hypotensive with a blood pressure of 60/40 mmHg. Furthermore, the patient is tachycardic and edematous. What is responsible for this patient's presentation? QID: 100471 Type & Select Correct Answer Type in at least one full word to see suggestions list 1 Free IgE binding to the antigen 3% (9/335) 2 IgE, on mast cell surfaces, binding to the antigen 83% (279/335) 3 IgE activation of complement 7% (23/335) 4 Complexes of IgE binding to the antigen 1% (3/335) 5 IgE, on eosinophils, binding to the antigen 5% (17/335) M 1 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic (M1.IM.13.37) A 30-year-old Caucasian male presents with hemoptysis and uremia. Blood tests show the presence of anti-basement membrane antibodies specific for collagen located in glomerular and pulmonary basement membranes. The patient undergoes plasmapheresis to help reduce the amount of anti-basement membrane antibodies. Which of the following diseases is of the same hypersensitivity category as this disease? QID: 100458 Type & Select Correct Answer Type in at least one full word to see suggestions list 1 Myasthenia gravis 66% (131/200) 2 Systemic lupus erythematosus 25% (50/200) 3 A PPD test 4% (9/200) 4 Seasonal allergies 1% (2/200) 5 Poison ivy rash 2% (5/200) M 1 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 1 Review Tested Concept Review Full Topic (M1.IM.13.4) A 32-year-old pregnant woman (para 2) presents to the clinic for a routine ultrasound; Figure A displays the ultrasound findings. The fetus has become anemic and levels of unconjugated bilirubin have increased dramatically. Which type of hypersensitivity reaction has occurred and what is mediating the disease state? QID: 100425 FIGURES: Type & Select Correct Answer Type in at least one full word to see suggestions list Return multiple choice1 Type I hypersensitivity; antibody-mediated opsonization 5% (17/338) 2 Type II hypersensitivity; antibody-mediated opsonization 70% (238/338) 3 Type II hypersensivity; cell killing via cytotoxic T cells 14% (47/338) 4 Type III hypersensitivity; cell killing via cytotoxic T cells 6% (19/338) 5 Type IV hypersensitivity; cell killing via NK cells 3% (9/338) M 1 Question Complexity Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic Sorry, this question is for Upgrade to PEAK All Videos (1) Login to View Community Videos Login to View Community Videos Type III Hypersensitivity Keshav Mudgal
E 10/21/2015 157 views 3.0 (1) Immunology | Hypersensitivity
Listen Now 18:30 min 4/11/2021 175 plays 3.0 (1) What type of hypersensitivity is a poison ivy reaction?Urushiol, the oily resin found in poison ivy, causes a type IV hypersensitivity reaction in up to 85% of people. Severe symptoms may require systemic corticosteroids.
Is poison ivy a type 4 reaction?Type 4 reactions are cell-mediated, which means they are controlled by T cells rather than antibodies. Type 4 reactions can be caused by: Poison ivy. Certain metals.
What is Type 1 hypersensitivity?Type I hypersensitivity is also known as an immediate reaction and involves immunoglobulin E (IgE) mediated release of antibodies against the soluble antigen. This results in mast cell degranulation and release of histamine and other inflammatory mediators.
What is a Type 4 hypersensitivity reaction?Type four hypersensitivity reaction is a cell-mediated reaction that can occur in response to contact with certain allergens resulting in what is called contact dermatitis or in response to some diagnostic procedures as in the tuberculin skin test. Certain allergens must be avoided to treat this condition.
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